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| Date | Insider | Role | Type | Shares | Price | Value | Chg% | SEC |
|---|---|---|---|---|---|---|---|---|
| 2025-11-28 | Noci Darlene | Chief Development Officer | Sale+OE | 645 | $107.85 | $69,563.25 | -1.2% | → |
| 2025-11-24 | Shair Matthew | - | Sell | 7,500 | $109.37 | $820,273.74 | -0.1% | → |
| 2025-11-24 | Flynn James E | - | Sell | 742,574 | $95.45 | $70,874,975.43 | -4.3% | → |
| 2025-11-18 | Balcom Alexandra | Chief Financial Officer | Sale+OE | 20,729 | $99.62 | $2,065,030.33 | -3.7% | → |
| 2025-11-17 | Miller Deborah Ann | Chief Legal Officer | Sale+OE | 24,200 | $105.50 | $2,552,998.98 | -13.4% | → |
| 2025-10-30 | Noci Darlene | Chief Development Officer | Sale+OE | 4,000 | $102.92 | $411,660.84 | -1.3% | → |
| 2025-10-30 | Miller Deborah Ann | Chief Legal Officer | Sale+OE | 21,800 | $103.16 | $2,248,943.44 | -4.1% | → |
| 2025-10-28 | Shair Matthew | - | Sell | 60,000 | $100.26 | $6,015,464.36 | -1.8% | → |
| 2025-10-20 | Miller Deborah Ann | Chief Legal Officer | Sale+OE | 5,000 | $94.91 | $474,550.00 | -9.2% | → |
| 2025-10-16 | Porter James Richard | President and CEO | Sale+OE | 27,000 | $90.63 | $2,447,020.92 | -2.6% | → |
| 2025-10-16 | Miller Deborah Ann | Chief Legal Officer | Sale+OE | 12,376 | $91.66 | $1,134,442.21 | -7.1% | → |
| 2025-10-15 | Balcom Alexandra | Chief Financial Officer | Sale+OE | 1,683 | $85.57 | $144,014.31 | -2.7% | → |
| 2025-10-15 | Pelish Henry E. | Chief Scientific Officer | Sale+OE | 14,205 | $90.04 | $1,279,018.20 | -17.7% | → |