| 2022-11-28 | Stueland Katherine | Chief Executive Officer | Buy | 185,185 | $0.54 | $99,999.90 | New | → |
| 2022-10-26 | White Karen Ann | Chief People Officer | Sale+OE | 1,994 | $1.02 | $2,033.48 | -10.9% | → |
| 2022-10-20 | Saad Kareem | Chief Transformation Officer | Sale+OE | 5,412 | $0.89 | $4,818.30 | -5.3% | → |
| 2022-10-17 | Ryan Jason | Executive Chairman | Sale+OE | 1,281 | $0.86 | $1,101.40 | -7.5% | → |
| 2022-10-03 | Saad Kareem | Chief Transformation Officer | Sale+OE | 2,669 | $0.94 | $2,515.00 | -3.1% | → |
| 2022-10-03 | White Karen Ann | Chief People Officer | Sale+OE | 1,429 | $0.94 | $1,346.55 | -9.4% | → |
| 2022-08-25 | Miao Richard | Former Interim CFO | Sale+OE | 3,473 | $1.20 | $4,167.60 | -12.3% | → |
| 2022-08-12 | Assad Shawn | Former CAO | Sale+OE | 4,663 | $1.90 | $8,844.31 | -5.6% | → |
| 2022-08-09 | Ro Isaac | Former CFO | Sale+OE | 20,245 | $1.99 | $40,216.69 | -7.7% | → |
| 2022-07-26 | White Karen Ann | Chief People Officer | Sale+OE | 2,069 | $1.47 | $3,041.43 | -14.8% | → |
| 2022-07-26 | Clark Daniel Emmett | Secretary and General Counsel | Sale+OE | 1,280 | $1.47 | $1,881.60 | -0.4% | → |
| 2022-07-26 | Prentice Anthony | Chief Product Officer | Sale+OE | 1,698 | $1.47 | $2,496.06 | -12.3% | → |
| 2022-07-20 | Saad Kareem | Chief Transformation Officer | Sale+OE | 5,311 | $1.60 | $8,497.60 | -6.5% | → |
| 2022-07-05 | Ro Isaac | Former CFO | Sale+OE | 2,296 | $1.32 | $3,027.74 | -1.1% | → |
| 2022-07-05 | Prentice Anthony | Former Chief Product Officer | Sale+OE | 1,828 | $1.32 | $2,410.58 | -12.7% | → |
| 2022-07-05 | Clark Daniel Emmett | Former Secretary and GC | Sale+OE | 1,207 | $1.32 | $1,591.67 | -0.4% | → |
| 2022-07-05 | Saad Kareem | Chief Transformation Officer | Sale+OE | 2,612 | $1.32 | $3,444.44 | -3.6% | → |
| 2022-07-05 | White Karen Ann | Chief People Officer | Sale+OE | 1,021 | $1.32 | $1,346.39 | -8.0% | → |
| 2022-07-05 | Miao Richard | Former Interim CFO | Sale+OE | 2,191 | $1.32 | $2,889.27 | -8.6% | → |
| 2022-05-20 | Schadt Eric | President & Chief R&D Officer | Buy | 100,000 | $1.92 | $192,480.00 | +69.7% | → |
| 2022-05-11 | Assad Shawn | Chief Accounting Officer | Sale+OE | 3,128 | $1.75 | $5,475.25 | -8.9% | → |
| 2022-05-10 | Ro Isaac | Chief Financial Officer | Sale+OE | 19,515 | $2.46 | $48,006.90 | -8.8% | → |
| 2022-04-29 | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 10% Owner | Buy | 6,250,000 | $4.00 | $25,000,000.00 | +7.1% | → |
| 2022-04-29 | Meister Keith A. | - | Buy | 11,437,500 | $4.00 | $45,750,000.00 | +73.8% | → |
| 2022-04-29 | Casdin Eli | - | Buy | 11,437,500 | $4.00 | $45,750,000.00 | +228.8% | → |
| 2022-04-29 | BTO Sema4 Holdings L.P. | 10% Owner | Buy | 2,500,000 | $4.00 | $10,000,000.00 | +10.0% | → |
| 2022-04-28 | Prentice Anthony | Chief Product Officer | Sell | 1,691 | $2.18 | $3,687.56 | -14.6% | → |
| 2022-04-28 | White Karen Ann | Chief People Officer | Sell | 1,430 | $2.18 | $3,117.69 | -13.1% | → |
| 2022-04-28 | Schadt Eric | President & Chief R&D Officer | Sell | 35,899 | $2.18 | $78,274.18 | -20.0% | → |
| 2022-04-28 | Clark Daniel Emmett | Secretary and General Counsel | Sell | 1,212 | $2.18 | $2,642.64 | -0.4% | → |
| 2022-04-20 | Saad Kareem | Chief Business Officer | Sale+OE | 6,269 | $2.49 | $15,609.81 | -8.9% | → |
| 2022-04-06 | Ro Isaac | Chief Financial Officer | Sell | 1,284 | $2.91 | $3,736.57 | -0.8% | → |
| 2022-02-11 | Assad Shawn | Chief Accounting Officer | Sale+OE | 3,647 | $3.64 | $13,275.08 | -12.8% | → |
| 2022-02-10 | Ro Isaac | Chief Financial Officer | Sale+OE | 21,735 | $3.60 | $78,241.65 | -12.2% | → |
| 2022-01-28 | Prentice Anthony | Chief Product Officer | Sell | 2,021 | $2.84 | $5,742.67 | -21.0% | → |
| 2022-01-28 | Saad Kareem | Chief Business Officer | Sell | 6,697 | $2.84 | $19,026.18 | -11.3% | → |
| 2022-01-28 | White Karen Ann | Chief People Officer | Sell | 1,776 | $2.84 | $5,046.15 | -21.6% | → |
| 2022-01-28 | Schadt Eric | Chief Executive Officer | Sell | 29,100 | $2.84 | $82,667.28 | -22.5% | → |
| 2022-01-28 | Clark Daniel Emmett | Secretary and General Counsel | Sell | 1,512 | $2.84 | $4,297.56 | -0.5% | → |
| 2021-11-29 | Ro Isaac | Chief Financial Officer | Sell | 12,115 | $6.63 | $80,322.45 | -9.5% | → |
| 2021-11-10 | Assad Shawn | Chief Accounting Officer | Sale+OE | 3,114 | $7.87 | $24,507.18 | -14.9% | → |
| 2021-11-08 | Ro Isaac | Chief Financial Officer | Sale+OE | 19,516 | $8.49 | $165,694.74 | -13.3% | → |
| 2021-10-25 | Prentice Anthony | Chief Product Officer | Sale+OE | 1,620 | $8.09 | $13,105.80 | -41.1% | → |
| 2021-10-25 | White Karen Ann | Chief People Officer | Sale+OE | 1,482 | $7.54 | $11,174.28 | -32.9% | → |
| 2021-10-25 | Saad Kareem | Chief Business Officer | Sale+OE | 16,608 | $7.54 | $125,224.32 | -30.7% | → |
| 2021-10-25 | Coffin James | President and COO | Sale+OE | 5,752 | $7.54 | $43,370.08 | -25.5% | → |
| 2021-10-25 | Ro Isaac | Chief Financial Officer | Sale+OE | 40,848 | $7.54 | $307,993.92 | -32.7% | → |