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| Date | Insider | Role | Type | Shares | Price | Value | Chg% | SEC |
|---|---|---|---|---|---|---|---|---|
| 2025-12-31 | Tousignant Jennifer | Chief Legal Officer | Sell | 2,272 | $31.16 | $70,795.52 | -100% | → |
| 2025-10-23 | Fairmount Funds Management LLC | - | Buy | 454,545 | $22.00 | $9,999,990.00 | +13.1% | → |
| 2024-09-27 | Beetham Thomas W. | Chief Operating Officer | Buy | 5,000 | $23.41 | $117,050.00 | +500.0% | → |
| 2024-09-27 | Mahoney Stephen F. | President and CEO | Buy | 21,400 | $23.33 | $499,262.00 | New | → |
| 2024-09-13 | Fairmount Funds Management LLC | - | Buy | 1,600,000 | $18.75 | $30,000,000.00 | +86.7% | → |
| 2024-01-22 | Fairmount Funds Management LLC | - | Buy | 476,190 | $21.00 | $9,999,990.00 | +34.9% | → |
| 2023-06-16 | Meisner Lara | Chief Legal Officer | Sale+OE | 2,296 | $28.02 | $64,342.83 | -3.7% | → |
| 2023-06-06 | Meisner Lara | Chief Legal Officer | Sale+OE | 7,500 | $24.82 | $186,136.24 | -7.7% | → |
| 2023-04-12 | Myers Scott Dunseth | Chief Executive Officer | Buy | 4,000 | $25.37 | $101,478.80 | +1.6% | → |
| 2023-03-13 | Myers Scott Dunseth | Chief Executive Officer | Buy | 5,500 | $29.15 | $160,324.45 | +2.2% | → |
| 2023-03-09 | Meisner Lara | General Counsel and Secretary | Sell | 29,971 | $29.07 | $871,256.97 | -100% | → |
| 2023-02-02 | Violin Jonathan | Chief Executive Officer | Sell | 50,000 | $36.80 | $1,840,000.00 | -10.4% | → |
| 2023-01-23 | Meisner Lara | General Counsel and Secretary | Sale+OE | 6,843 | $35.66 | $244,021.38 | -100% | → |
| 2023-01-17 | Katz Barrett | Chief Medical Officer | Sale+OE | 29,000 | $37.18 | $1,078,260.60 | -100% | → |
| 2023-01-10 | Katz Barrett | Chief Medical Officer | Sale+OE | 60,000 | $34.82 | $2,089,472.02 | -100% | → |
| 2022-12-21 | Meisner Lara | General Counsel and Secretary | Sale+OE | 16,926 | $29.15 | $493,397.94 | -100% | → |
| 2022-12-16 | Meisner Lara | General Counsel and Secretary | Sale+OE | 1,597 | $28.37 | $45,310.68 | -100% | → |
| 2022-12-14 | Meisner Lara | General Counsel and Secretary | Sale+OE | 16,256 | $28.12 | $457,076.72 | -100% | → |
| 2022-11-15 | Meisner Lara | General Counsel and Secretary | Sale+OE | 8,125 | $22.05 | $179,156.25 | -100% | → |
| 2022-08-17 | Fairmount Funds Management LLC | - | Buy | 425,531 | $23.50 | $9,999,978.50 | +45.4% | → |
| 2022-06-01 | Violin Jonathan | Chief Executive Officer | Sell | 30,000 | $12.20 | $366,000.00 | -5.9% | → |
| 2022-05-02 | Violin Jonathan | Chief Executive Officer | Sell | 30,000 | $13.04 | $391,200.00 | -5.5% | → |
| 2022-04-04 | Violin Jonathan | Chief Executive Officer | Sell | 30,000 | $18.92 | $567,636.00 | -2.7% | → |
| 2022-03-02 | Violin Jonathan | Chief Executive Officer | Sell | 30,000 | $17.65 | $529,491.24 | -2.5% | → |
| 2022-02-03 | Violin Jonathan | Chief Executive Officer | Sell | 30,000 | $19.09 | $572,818.29 | -1.6% | → |
| 2021-09-23 | Frazier Life Sciences Public Fund, L.P. | 10% Owner | Buy | 200,000 | $11.00 | $2,200,000.00 | +15.3% | → |
| 2021-09-21 | Fairmount Funds Management LLC | Director, 10% Owner | Buy | 909,000 | $11.00 | $9,999,000.00 | +3,109% | → |
| 2020-11-13 | Logos Global Master Fund LP | - | Buy | 476,667 | $4.76 | $2,270,483.95 | +3.8% | → |
| 2018-10-11 | Hughes Thomas E. | Director | Buy | 10,000 | $4.77 | $47,697.00 | +353.7% | → |
| 2018-02-13 | Levy Adam Scott | Chief Business Officer | Buy | 9,090 | $5.50 | $49,995.00 | +626.9% | → |
| 2018-02-13 | Booth Bruce | Director | Buy | 545,454 | $5.50 | $2,999,997.00 | +67.7% | → |
| 2017-12-20 | Hughes Thomas E. | Director | Sell | 12,000 | $8.00 | $96,000.00 | -80.9% | → |
| 2017-06-22 | Levy Adam Scott | Chief Business Officer | Buy | 200 | $7.55 | $1,510.00 | New | → |
| 2017-03-10 | LEFKOFF KYLE | Director | Sell | 5,800 | $14.34 | $83,190.44 | -0.6% | → |
| 2017-03-08 | LEFKOFF KYLE | Director | Sell | 5,000 | $14.70 | $73,514.00 | -1.1% | → |