| 2019-03-15 | Goldstein Michael H. | Chief Medical Officer | Buy | 10,000 | $4.15 | $41,500.00 | +271.3% | → |
| 2019-03-13 | LINDSTROM RICHARD L MD | Director | Buy | 56,441 | $4.33 | $244,389.53 | +129.6% | → |
| 2018-12-14 | Hanley Kevin F. | See Remarks | Buy | 10,000 | $5.50 | $55,000.00 | +100.0% | → |
| 2018-12-10 | Hanley Kevin F. | SEE REMARKS | Buy | 10,000 | $5.60 | $56,000.00 | New | → |
| 2018-12-06 | Bollag Daniel M | See Remarks | Buy | 17,400 | $5.76 | $100,224.00 | +70.4% | → |
| 2018-08-20 | Mattessich Antony C. | President & CEO | Buy | 20,000 | $5.95 | $119,000.00 | +52.8% | → |
| 2018-08-14 | Notman Donald | Chief Financial Officer | Buy | 12,500 | $6.29 | $78,625.00 | +260.4% | → |
| 2018-08-10 | Mattessich Antony C. | President and CEO | Buy | 16,900 | $6.23 | $105,287.00 | +80.5% | → |
| 2017-12-12 | Mattessich Antony C. | President and C.E.O. | Buy | 21,000 | $4.29 | $90,090.00 | New | → |
| 2017-12-07 | Notman Donald | Chief Financial Officer | Buy | 4,800 | $4.00 | $19,200.00 | New | → |
| 2017-12-06 | Bollag Daniel M | See Remarks | Buy | 24,700 | $3.93 | $97,071.00 | New | → |
| 2017-11-16 | Sawhney Amarpreet | Exec. Chairman of the Board | Buy | 19,000 | $5.18 | $98,420.00 | +2.8% | → |
| 2016-12-15 | Sawhney Amarpreet | President and CEO | Buy | 45,300 | $7.85 | $355,605.00 | +7.2% | → |
| 2016-06-09 | Sawhney Amarpreet | President and CEO | Buy | 10,000 | $6.70 | $67,000.00 | +1.8% | → |
| 2015-11-17 | Sawhney Amarpreet | President and CEO | Buy | 10,000 | $8.25 | $82,500.00 | +1.8% | → |
| 2015-09-15 | Fortune James | Chief Operating Officer | Sell | 9,470 | $17.16 | $162,505.20 | -7.8% | → |
| 2015-09-14 | Sawhney Amarpreet | President and CEO | Buy | 15,000 | $16.50 | $247,456.32 | +1.4% | → |
| 2015-06-15 | Warden Charles M | Director, 10% Owner | Sell | 320,000 | $22.00 | $7,040,000.00 | -12.6% | → |
| 2015-06-15 | Versant Venture Capital III, L.P. | 10% Owner | Sell | 320,000 | $22.00 | $7,040,000.00 | -12.6% | → |
| 2015-06-10 | Versant Venture Capital III, L.P. | 10% Owner | Sell | 427,000 | $22.00 | $9,394,000.00 | -14.4% | → |
| 2015-06-10 | Warden Charles M | Director, 10% Owner | Sell | 427,000 | $22.00 | $9,394,000.00 | -14.4% | → |
| 2015-06-10 | SVLSF IV, LLC | 10% Owner | Sell | 1,119,000 | $22.00 | $24,618,000.00 | -14.4% | → |
| 2015-02-02 | Polaris Venture Management Co. V, L.L.C. | 10% Owner | Sell | 500,000 | $29.50 | $14,750,000.00 | -19.8% | → |