| 2023-01-31 | Lippoldt Darin | Chief Legal Officer | Sell | 1,250 | $109.97 | $137,464.00 | -4.0% | → |
| 2023-01-31 | Lloyd-Smith Malcolm | Chief Integration Officer | Sell | 1,666 | $110.02 | $183,290.49 | -5.5% | → |
| 2023-01-31 | Onyia Jude | Chief Scientific Officer | Sell | 126 | $108.48 | $13,668.48 | -4.8% | → |
| 2023-01-31 | ABERNETHY MATT | Chief Financial Officer | Sell | 1,283 | $109.98 | $141,107.80 | -5.7% | → |
| 2023-01-31 | ROBERTS EIRY | Chief Medical Officer | Sell | 1,457 | $109.99 | $160,253.54 | -5.3% | → |
| 2023-01-06 | BENEVICH ERIC | Chief Commercial Officer | Sale+OE | 400 | $125.00 | $50,000.00 | -2.5% | → |
| 2023-01-03 | POPS RICHARD F | Director | Sale+OE | 15,000 | $119.20 | $1,788,045.00 | -33.7% | → |
| 2023-01-03 | SHERWIN STEPHEN A | Director | Sale+OE | 30,000 | $118.86 | $3,565,728.00 | -37.4% | → |
| 2022-11-30 | BENEVICH ERIC | Chief Commercial Officer | Sale+OE | 50,000 | $125.90 | $6,295,085.00 | -51.6% | → |
| 2022-11-29 | Onyia Jude | Chief Scientific Officer | Sell | 2,331 | $121.90 | $284,160.09 | -49.6% | → |
| 2022-11-10 | BENEVICH ERIC | Chief Commercial Officer | Sale+OE | 24,693 | $125.33 | $3,094,855.59 | -44.1% | → |
| 2022-11-08 | Cooke Julie | Chief Human Resources Officer | Sale+OE | 5,592 | $124.99 | $698,949.11 | -27.0% | → |
| 2022-11-08 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 5,082 | $125.04 | $635,441.59 | -14.8% | → |
| 2022-11-03 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 4,518 | $125.02 | $564,851.20 | -13.4% | → |
| 2022-11-03 | Cooke Julie | Chief Human Resources Officer | Sale+OE | 8,408 | $125.00 | $1,050,996.96 | -21.8% | → |
| 2022-11-03 | BENEVICH ERIC | Chief Commercial Officer | Sale+OE | 9,368 | $125.02 | $1,171,182.95 | -23.0% | → |
| 2022-11-02 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 10,400 | $120.28 | $1,250,899.00 | -15.1% | → |
| 2022-10-31 | Boyer David W. | Chief Corp. Affairs Officer | Sell | 1,295 | $114.12 | $147,785.40 | -30.7% | → |
| 2022-10-31 | LYONS GARY A | Director | Sale+OE | 15,000 | $114.76 | $1,721,403.00 | -6.9% | → |
| 2022-10-27 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 10,000 | $115.03 | $1,150,297.26 | -14.6% | → |
| 2022-10-17 | BENEVICH ERIC | Chief Commercial Officer | Sell | 4,960 | $110.82 | $549,681.58 | -24.1% | → |
| 2022-10-04 | LYONS GARY A | Director | Sell | 5,000 | $110.54 | $552,711.00 | -2.4% | → |
| 2022-10-04 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 10,000 | $111.04 | $1,110,446.00 | -25.5% | → |
| 2022-10-03 | Boyer David W. | Chief Corp. Affairs Officer | Sell | 1,437 | $106.59 | $153,169.83 | -25.4% | → |
| 2022-08-12 | Lloyd-Smith Malcolm | Chief Regulatory Officer | Sale+OE | 21,533 | $105.95 | $2,281,330.91 | -53.3% | → |
| 2022-08-05 | Cooke Julie | Chief Human Resources Officer | Sell | 1,816 | $100.00 | $181,600.00 | -10.7% | → |
| 2022-06-27 | Cooke Julie | Chief Human Resources Officer | Sell | 754 | $100.00 | $75,400.00 | -4.3% | → |
| 2022-05-09 | POPS RICHARD F | Director | Sale+OE | 15,000 | $76.30 | $1,144,462.50 | -20.3% | → |
| 2022-04-25 | LYONS GARY A | Director | Sale+OE | 15,000 | $92.76 | $1,391,392.50 | -6.7% | → |
| 2022-04-01 | RASTETTER WILLIAM H | Director | Sale+OE | 10,728 | $94.93 | $1,018,366.13 | -24.0% | → |
| 2022-03-22 | Lippoldt Darin | Chief Legal Officer | Sell | 8,755 | $95.05 | $832,156.21 | -11.5% | → |
| 2022-02-08 | ABERNETHY MATT | Chief Financial Officer | Sell | 980 | $79.65 | $78,057.59 | -4.6% | → |
| 2022-02-08 | Gano Kyle | Chief Business Development Off | Sell | 980 | $79.67 | $78,078.56 | -0.9% | → |
| 2022-02-08 | BENEVICH ERIC | Chief Commercial Officer | Sell | 980 | $79.67 | $78,072.58 | -4.6% | → |
| 2022-02-08 | Cooke Julie | Chief Human Resources Officer | Sell | 700 | $79.56 | $55,689.13 | -3.9% | → |
| 2022-02-08 | GORMAN KEVIN CHARLES | Chief Executive Officer | Sell | 2,274 | $79.49 | $180,767.54 | -0.5% | → |
| 2022-02-08 | Lippoldt Darin | Chief Legal Officer | Sell | 911 | $79.51 | $72,434.52 | -2.3% | → |
| 2022-02-08 | Lloyd-Smith Malcolm | Chief Regulatory Officer | Sell | 701 | $79.53 | $55,750.60 | -3.6% | → |
| 2022-02-08 | ROBERTS EIRY | Chief Medical Officer | Sell | 980 | $79.52 | $77,930.58 | -3.8% | → |
| 2022-02-08 | Boyer David W. | Chief Corp. Affairs Officer | Sell | 700 | $79.62 | $55,736.03 | -19.3% | → |