| 2018-11-06 | Bozigian Haig P. | Chief Development Officer | Sale+OE | 9,420 | $110.10 | $1,037,167.43 | -6.5% | → |
| 2018-11-06 | Lloyd-Smith Malcolm | Chief Regulatory Officer | Sale+OE | 5,700 | $110.02 | $627,095.76 | -27.1% | → |
| 2018-11-02 | LYONS GARY A | Director | Sell | 15,000 | $114.41 | $1,716,213.00 | -5.8% | → |
| 2018-10-29 | POPS RICHARD F | Director | Sell | 5,500 | $107.13 | $589,237.00 | -12.7% | → |
| 2018-08-01 | Gano Kyle | Chief Business Development Off | Sale+OE | 28,266 | $115.00 | $3,250,590.00 | -26.4% | → |
| 2018-08-01 | Grigoriadis Dimitri E. | Chief Research Officer | Sale+OE | 23,022 | $110.00 | $2,532,420.00 | -21.7% | → |
| 2018-06-20 | Grigoriadis Dimitri E. | Chief Research Officer | Sale+OE | 23,000 | $105.00 | $2,415,000.00 | -21.7% | → |
| 2018-06-14 | Grigoriadis Dimitri E. | Chief Research Officer | Sale+OE | 86,963 | $99.48 | $8,650,738.28 | -25.9% | → |
| 2018-06-13 | LYONS GARY A | Director | Sell | 15,000 | $99.24 | $1,488,549.00 | -5.4% | → |
| 2018-06-11 | SHERWIN STEPHEN A | Director | Sell | 10,000 | $98.44 | $984,420.00 | -17.4% | → |
| 2018-06-01 | BENEVICH ERIC | Chief Commercial Officer | Sell | 12,350 | $97.34 | $1,202,163.82 | -42.5% | → |
| 2018-05-07 | Nevinny Corinne H | Director | Sell | 5,000 | $83.13 | $415,625.00 | -10.4% | → |
| 2018-05-01 | GORMAN KEVIN CHARLES | Chief Executive Officer | Sale+OE | 126,832 | $80.75 | $10,241,734.73 | -26.8% | → |
| 2018-03-05 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 1,979 | $88.47 | $175,089.65 | -11.0% | → |
| 2018-03-05 | Gano Kyle | Chief Business Development Off | Sale+OE | 23,650 | $90.00 | $2,128,500.00 | -23.1% | → |
| 2018-03-05 | Bozigian Haig P. | Chief Development Officer | Sale+OE | 75,873 | $90.00 | $6,828,570.00 | -21.8% | → |
| 2018-02-15 | LYONS GARY A | Director | Sell | 5,000 | $84.67 | $423,341.00 | -1.9% | → |
| 2018-02-12 | Grigoriadis Dimitri E. | Chief Research Officer | Sale+OE | 86,368 | $78.32 | $6,764,173.36 | -34.2% | → |
| 2018-02-06 | GORMAN KEVIN CHARLES | Chief Executive Officer | Sale+OE | 105,983 | $80.25 | $8,504,783.91 | -9.4% | → |
| 2018-02-05 | Bozigian Haig P. | Chief Development Officer | Sell | 2,262 | $83.10 | $187,976.53 | -0.8% | → |
| 2018-02-05 | OBrien Christopher Flint | Former Chief Medical Officer | Sell | 2,613 | $83.18 | $217,341.46 | -2.4% | → |
| 2018-02-05 | LYONS GARY A | Director | Sell | 5,000 | $83.08 | $415,380.00 | -1.8% | → |
| 2018-02-05 | Lloyd-Smith Malcolm | Chief Regulatory Officer | Sell | 960 | $83.19 | $79,862.59 | -6.4% | → |
| 2018-02-05 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 2,737 | $83.12 | $227,494.37 | -9.0% | → |
| 2018-02-05 | Grigoriadis Dimitri E. | Chief Research Officer | Sell | 2,046 | $83.09 | $169,997.32 | -1.2% | → |
| 2018-02-05 | BENEVICH ERIC | Chief Commercial Officer | Sell | 820 | $83.14 | $68,174.23 | -24.1% | → |
| 2018-02-05 | Gano Kyle | Chief Business Development Off | Sell | 2,046 | $83.05 | $169,913.91 | -1.3% | → |
| 2018-01-24 | RASTETTER WILLIAM H | Director | Sale+OE | 9,500 | $90.00 | $855,000.00 | -27.7% | → |
| 2018-01-16 | OBrien Christopher Flint | Chief Medical Officer | Sell | 1,750 | $79.14 | $138,499.03 | -3.3% | → |
| 2018-01-16 | Grigoriadis Dimitri E. | Chief Research Officer | Sell | 1,625 | $79.12 | $128,563.01 | -2.0% | → |
| 2018-01-16 | GORMAN KEVIN CHARLES | Chief Executive Officer | Sell | 3,750 | $78.89 | $295,819.88 | -1.1% | → |
| 2018-01-16 | Gano Kyle | Chief Business Development Off | Sell | 1,625 | $79.05 | $128,459.50 | -2.1% | → |
| 2018-01-16 | Bozigian Haig P. | Chief Development Officer | Sell | 1,625 | $79.12 | $128,574.71 | -1.2% | → |
| 2018-01-03 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 1,979 | $79.36 | $157,053.44 | -13.1% | → |
| 2018-01-02 | Lloyd-Smith Malcolm | Chief Regulatory Officer | Sale+OE | 18,084 | $77.52 | $1,401,822.85 | -58.1% | → |
| 2017-12-28 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 15,237 | $75.00 | $1,142,775.00 | -53.7% | → |
| 2017-12-08 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 2,955 | $75.00 | $221,625.00 | -18.3% | → |
| 2017-12-04 | Lippoldt Darin | Chief Legal Officer | Sale+OE | 6,279 | $75.04 | $471,159.83 | -32.3% | → |
| 2017-12-01 | LYONS GARY A | Director | Sell | 10,000 | $72.92 | $729,182.00 | -3.5% | → |