| 2022-10-26 | Reumuth Mary | CHIEF FINANCIAL OFFICER | Sell | 194 | $6.51 | $1,262.94 | -7.4% | → |
| 2022-10-26 | Brazzell Romulus K | SEE REMARKS | Sell | 261 | $6.51 | $1,699.11 | -4.3% | → |
| 2022-10-26 | Iwicki Mark T | CHIEF EXECUTIVE OFFICER | Sell | 561 | $6.52 | $3,657.72 | -11.2% | → |
| 2022-06-27 | Trachtenberg Eric | SEE REMARKS | Sell | 2,613 | $0.37 | $966.81 | -2.3% | → |
| 2022-06-27 | Reumuth Mary | CHIEF FINANCIAL OFFICER | Sell | 2,613 | $0.37 | $966.81 | -2.0% | → |
| 2022-06-27 | Brazzell Romulus K | SEE REMARKS | Sell | 3,144 | $0.37 | $1,163.28 | -1.1% | → |
| 2022-06-27 | Bazemore Todd | SEE REMARKS | Sell | 3,092 | $0.37 | $1,144.04 | -2.6% | → |
| 2022-06-27 | Iwicki Mark T | CHIEF EXECUTIVE OFFICER | Sell | 7,975 | $0.37 | $2,950.75 | -3.1% | → |
| 2022-05-26 | RA CAPITAL MANAGEMENT, L.P. | - | Sell | 1,005,686 | $0.36 | $365,667.43 | -12.5% | → |
| 2022-05-25 | RA CAPITAL MANAGEMENT, L.P. | - | Sell | 2,829,314 | $0.53 | $1,488,844.33 | -9.4% | → |
| 2022-01-04 | Reumuth Mary | CHIEF FINANCIAL OFFICER | Sell | 2,850 | $1.30 | $3,705.00 | -2.1% | → |
| 2022-01-04 | Brazzell Romulus K | SEE REMARKS | Sell | 3,504 | $1.30 | $4,555.20 | -1.2% | → |
| 2022-01-04 | Bazemore Todd | SEE REMARKS | Sell | 3,454 | $1.30 | $4,490.20 | -2.8% | → |
| 2022-01-04 | Iwicki Mark T | CHIEF EXECUTIVE OFFICER | Sell | 9,518 | $1.30 | $12,373.40 | -3.5% | → |
| 2022-01-04 | Trachtenberg Eric | SEE REMARKS | Sell | 2,850 | $1.30 | $3,705.00 | -2.4% | → |
| 2021-10-27 | Chen Hongming | CHIEF SCIENTIFIC OFFICER | Sell | 30,500 | $1.81 | $55,321.02 | -6.6% | → |
| 2021-10-26 | Trachtenberg Eric | SEE REMARKS | Sell | 9,449 | $1.80 | $17,008.20 | -7.5% | → |
| 2021-10-26 | Reumuth Mary | CHIEF FINANCIAL OFFICER | Sell | 9,449 | $1.80 | $17,008.20 | -6.5% | → |
| 2021-10-26 | Bazemore Todd | CHIEF OPERATING OFFICER | Sell | 12,544 | $1.80 | $22,579.20 | -9.3% | → |
| 2021-10-26 | Brazzell Romulus K | CHIEF MEDICAL OFFICER | Sell | 12,757 | $1.80 | $22,962.60 | -4.2% | → |
| 2021-10-26 | Iwicki Mark T | CHIEF EXECUTIVE OFFICER | Sell | 27,598 | $1.80 | $49,676.40 | -9.3% | → |
| 2021-06-29 | Chen Hongming | CHIEF SCIENTIFIC OFFICER | Sell | 5,548 | $5.56 | $30,846.88 | -2.3% | → |
| 2021-06-28 | Chen Hongming | CHIEF SCIENTIFIC OFFICER | Sell | 2,452 | $5.77 | $14,148.04 | -1.0% | → |
| 2021-06-28 | Brazzell Romulus K | CHIEF MEDICAL OFFICER | Sell | 3,034 | $5.77 | $17,506.18 | -1.0% | → |
| 2021-06-28 | Trachtenberg Eric | SEE REMARKS | Sell | 2,452 | $5.77 | $14,148.04 | -1.9% | → |
| 2021-06-28 | Reumuth Mary | CHIEF FINANCIAL OFFICER | Sell | 2,452 | $5.77 | $14,148.04 | -1.7% | → |
| 2021-06-28 | Bazemore Todd | CHIEF OPERATING OFFICER | Sell | 2,911 | $5.77 | $16,796.47 | -100% | → |
| 2021-06-28 | Iwicki Mark T | CHIEF EXECUTIVE OFFICER | Sell | 7,586 | $5.77 | $43,771.22 | -2.5% | → |
| 2020-10-22 | Bazemore Todd | Chief Operating Officer | Buy | 42 | $7.88 | $330.78 | +2,100% | → |
| 2020-03-16 | Bazemore Todd | Chief Operating Officer | Buy | 10,000 | $5.75 | $57,500.00 | New | → |
| 2020-03-13 | Grunberg Gregory | - | Buy | 2,534,854 | $7.89 | $19,999,998.06 | New | → |
| 2020-03-13 | Shah Rajeev M. | - | Buy | 6,337,135 | $7.89 | $49,999,995.15 | +139.7% | → |
| 2020-03-13 | RA CAPITAL MANAGEMENT, L.P. | - | Buy | 6,337,135 | $7.89 | $49,999,995.15 | +139.7% | → |
| 2019-05-30 | Rosen Howard B | Director | Buy | 5,000 | $5.42 | $27,100.00 | +154.3% | → |
| 2018-10-05 | Grunberg Gregory | - | Buy | 606,060 | $8.25 | $4,999,995.00 | +26.7% | → |
| 2018-10-03 | Shah Rajeev M. | - | Buy | 2,424,242 | $8.25 | $19,999,996.50 | +114.7% | → |
| 2018-10-03 | RA CAPITAL MANAGEMENT, LLC | - | Buy | 2,424,242 | $8.25 | $19,999,996.50 | +114.7% | → |
| 2018-02-08 | ORBIMED ADVISORS LLC | - | Buy | 25,000 | $12.93 | $323,250.00 | +0.7% | → |
| 2018-02-02 | ORBIMED ADVISORS LLC | - | Buy | 37,840 | $14.73 | $557,383.20 | +1.1% | → |
| 2018-02-01 | ORBIMED ADVISORS LLC | - | Buy | 362,240 | $15.00 | $5,433,371.60 | +5.7% | → |
| 2018-01-29 | ORBIMED ADVISORS LLC | - | Buy | 72,760 | $14.97 | $1,089,306.80 | +1.2% | → |
| 2018-01-24 | ORBIMED ADVISORS LLC | - | Buy | 144,000 | $14.95 | $2,152,639.04 | +1.7% | → |