CRVS

Insider Ownership

Role	Insider	Shares	Value	30d
?	ORBIMED ADVISORS LLC	8.34M	$173.00M	-
?	Thompson Peter A.	8.34M	$173.00M	-
CEO	MILLER RICHARD A MD	1.14M	$23.58M	-
CEO	MILLER RICHARD A MD	1.00M	$20.74M	-
Other	Jones William Benton	400.0K	$8.30M	-
CFO	LEA LEIV	400.0K	$8.30M	-
Other	Jones William Benton	173.1K	$3.59M	-
Other	Arcara Jeffrey	100.0K	$2.07M	-
?	Moore David Scott	30.0K	$622.2K	-
?	van den Broek Richard	30.0K	$622.2K	-
?	Grais Linda	15.0K	$311.1K	-
?	CLARK IAN T	15.0K	$311.1K	-
?	Morrison Scott W	15.0K	$311.1K	-

23 transactions · page 3

Date	Insider	Role	Type	Shares	Price	Value	Chg%	SEC
2016-06-09	Thompson Peter A.	Director, 10% Owner	Buy	30,000	$12.95	$388,500.00	+0.6%	→
2016-05-20	ORBIMED ADVISORS LLC	Director, 10% Owner	Buy	4,716	$13.09	$61,732.44	-	→
2016-05-20	Thompson Peter A.	Director, 10% Owner	Buy	4,716	$13.09	$61,732.44	-	→
2016-05-19	Thompson Peter A.	Director, 10% Owner	Buy	6,800	$11.77	$80,035.04	-	→
2016-05-19	ORBIMED ADVISORS LLC	Director	Buy	6,800	$11.77	$80,035.04	-	→
2016-05-13	MILLER RICHARD A MD	President and CEO	Buy	30,300	$10.00	$302,981.01	+1.4%	→
2016-05-12	Novo A/S	10% Owner	Buy	70,000	$10.00	$700,000.00	+2.2%	→
2016-03-29	ADAMS STREET PARTNERS LLC	10% Owner	Buy	200,000	$15.00	$3,000,000.00	+8.0%	→
2016-03-29	Gould Terry P	Director, 10% Owner	Buy	200,000	$15.00	$3,000,000.00	+8.0%	→
2016-03-29	Novo A/S	10% Owner	Buy	666,666	$15.00	$9,999,990.00	+26.8%	→
2016-03-29	Thompson Peter A.	Director, 10% Owner	Buy	550,000	$15.00	$8,250,000.00	+11.7%	→
2016-03-29	ORBIMED ADVISORS LLC	Director, 10% Owner	Buy	550,000	$15.00	$8,250,000.00	+11.7%	→