| 2018-06-12 | Heffernan Michael Thomas | Chairman, President and CEO | Sell | 150,000 | $25.27 | $3,790,938.86 | -15.3% | → |
| 2018-06-01 | Ciaffoni Joseph | Chief Operating Officer | Sale+OE | 79,683 | $22.59 | $1,799,712.87 | -20.3% | → |
| 2018-05-10 | Heffernan Michael Thomas | Chairman, President and CEO | Sell | 7,100 | $26.21 | $186,100.00 | -0.7% | → |
| 2018-05-10 | Fleming Alison B | Chief Technical Officer | Sale+OE | 12,224 | $22.23 | $271,752.00 | -1.3% | → |
| 2018-04-19 | Heffernan Michael Thomas | Chairman, President and CEO | Sell | 44,400 | $26.00 | $1,154,401.00 | -3.9% | → |
| 2018-01-23 | Heffernan Michael Thomas | Chairman, President and CEO | Sell | 20,000 | $25.01 | $500,164.08 | -1.9% | → |
| 2018-01-19 | Heffernan Michael Thomas | Chairman, President and CEO | Sell | 20,000 | $22.50 | $450,000.00 | -3.6% | → |
| 2018-01-19 | Fleming Alison B | Chief Technology Officer | Sale+OE | 3,336 | $23.00 | $76,728.00 | -2.9% | → |
| 2018-01-10 | Fleming Alison B | Chief Technology Officer | Sale+OE | 6,928 | $19.07 | $132,116.96 | -21.2% | → |
| 2017-12-08 | Hirsch David | Director, 10% Owner | Sell | 1,000,000 | $17.34 | $17,340,000.00 | -30.1% | → |
| 2017-12-08 | Longitude Capital Partners, LLC | 10% Owner | Sell | 1,000,000 | $17.34 | $17,340,000.00 | -30.1% | → |
| 2017-11-21 | Fleming Alison B | Chief Technology Officer | Sale+OE | 4,601 | $17.25 | $79,361.00 | -4.2% | → |
| 2017-11-15 | Heffernan Michael Thomas | Chairman, President and CEO | Sell | 50,000 | $15.53 | $776,500.00 | -8.2% | → |
| 2017-05-12 | Brannelly Paul | Executive Vice President & CFO | Buy | 10,000 | $9.18 | $91,800.00 | +10.0% | → |
| 2016-08-12 | Fallon John A. | Director | Buy | 2,375 | $10.59 | $25,151.25 | New | → |
| 2015-05-12 | Hirsch David | Director, 10% Owner | Buy | 200,000 | $12.00 | $2,400,000.00 | +6.4% | → |
| 2015-05-12 | Longitude Capital Partners, LLC | 10% Owner | Buy | 200,000 | $12.00 | $2,400,000.00 | +6.4% | → |
| 2015-05-12 | Heron Patrick J | Director, 10% Owner | Buy | 150,000 | $12.00 | $1,800,000.00 | +8.6% | → |
| 2015-05-12 | Frazier Healthcare VI, L.P. | 10% Owner | Buy | 150,000 | $12.00 | $1,800,000.00 | +8.6% | → |
| 2015-05-12 | Freund John Gordon | Director, 10% Owner | Buy | 150,000 | $12.00 | $1,800,000.00 | +5.4% | → |
| 2015-05-12 | TPG Group Holdings (SBS) Advisors, Inc. | Former 10% Owner | Buy | 100,000 | $12.00 | $1,200,000.00 | +8.2% | → |
| 2015-05-12 | Skyline Venture Partners V LP | 10% Owner | Buy | 150,000 | $12.00 | $1,800,000.00 | +5.4% | → |