| 2015-08-17 | Higgons John Duncan | Chief Operating Officer | Sale+OE | 20,000 | $92.24 | $1,844,800.00 | -13.2% | → |
| 2015-08-10 | Biller Scott | Chief Scientific Officer | Sale+OE | 5,500 | $100.00 | $550,000.00 | -13.9% | → |
| 2015-08-03 | Schenkein David P | Chief Executive Officer | Sale+OE | 8,000 | $110.60 | $884,800.00 | -3.3% | → |
| 2015-07-23 | Goddard Glenn | Senior Vice President, Finance | Sale+OE | 7,000 | $120.45 | $843,150.00 | -100% | → |
| 2015-07-20 | Biller Scott | Chief Scientific Officer | Sale+OE | 5,500 | $113.87 | $626,285.00 | -13.9% | → |
| 2015-07-17 | Goddard Glenn | Senior Vice President, Finance | Sale+OE | 13,000 | $113.71 | $1,478,230.00 | -100% | → |
| 2015-07-16 | Higgons John Duncan | Chief Operating Officer | Sale+OE | 20,000 | $114.02 | $2,280,400.00 | -14.1% | → |
| 2015-07-16 | Cantley Lewis Clayton Jr. | Director | Sell | 9,704 | $114.28 | $1,108,924.60 | -1.5% | → |
| 2015-06-25 | Cantley Lewis Clayton Jr. | Director | Sell | 9,704 | $105.13 | $1,020,157.26 | -1.5% | → |
| 2015-06-15 | Higgons John Duncan | Chief Operating Officer | Sell | 7,000 | $105.23 | $736,610.00 | -5.4% | → |
| 2015-06-08 | Biller Scott | Chief Scientific Officer | Sell | 5,500 | $121.85 | $670,175.00 | -12.9% | → |
| 2015-06-01 | Bowden Christopher | Chief Medical Officer | Sale+OE | 5,000 | $120.67 | $603,350.00 | -100% | → |
| 2015-06-01 | Schenkein David P | Chief Executive Officer | Sell | 13,000 | $120.67 | $1,568,710.00 | -4.0% | → |
| 2015-05-27 | Goddard Glenn | Senior Vice President, Finance | Sale+OE | 2,171 | $120.05 | $260,628.55 | -100% | → |
| 2015-05-27 | Schenkein David P | Chief Executive Officer | Sell | 8,929 | $120.05 | $1,071,926.45 | -9.4% | → |
| 2015-05-20 | Cantley Lewis Clayton Jr. | Director | Sell | 9,704 | $116.64 | $1,131,850.30 | -1.4% | → |
| 2015-05-15 | Higgons John Duncan | Chief Operating Officer | Sell | 7,417 | $112.89 | $837,305.13 | -7.0% | → |
| 2015-05-12 | Schenkein David P | Chief Executive Officer | Sell | 5,200 | $110.02 | $572,093.86 | -2.6% | → |
| 2015-05-08 | Schenkein David P | Chief Executive Officer | Sale+OE | 3,900 | $101.32 | $395,148.00 | -1.1% | → |
| 2015-05-07 | Biller Scott | Chief Scientific Officer | Sell | 11,000 | $96.98 | $1,066,780.00 | -13.0% | → |
| 2015-05-01 | Schenkein David P | Chief Executive Officer | Sell | 3,900 | $93.63 | $365,157.00 | -1.7% | → |
| 2015-04-24 | Cantley Lewis Clayton Jr. | Director | Sell | 9,704 | $105.15 | $1,020,351.34 | -1.4% | → |